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Article

Inactivation gating of Kv7.1 channels does not involve concerted cooperative subunit interactions.

Channels (Austin, Tex.) - 1 Jan 2018

Meisel Eshcar, Tobelaim William, Dvir Meidan, Haitin Yoni, Peretz Asher, Attali Bernard

Abstract excerpt

Inactivation is an intrinsic property of numerous voltage-gated K+ (Kv) channels and can occur by N-type or/and C-type mechanisms. N-type inactivation is a fast, voltage independent process, coupled to activation, with each inactivation particle of a tetrameric channel acting independently. In N-type inactivation, a single inactivation particle is necessary and sufficient to occlude the pore. C-type inactivation...

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Identifiers

PMID: 29451064
DOI: 10.1080/19336950.2018.1441649
PMCID: PMC5972808

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