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Article

Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts.

Molecular biology of the cell - 1 Jul 2003

Lamorte Louie, Rodrigues Sonia, Sangwan Veena, Turner Christopher E, Park Morag

Abstract excerpt

We have previously demonstrated that the CrkII and CrkL adapter proteins are required for the spreading of epithelial colonies and the breakdown of adherens junctions in response to hepatocyte growth factor. When overexpressed, CrkII and CrkL promote lamellipodia formation, cell spreading, and the loss of epithelial adherens junctions in the absence of hepatocyte growth factor. The exact mechanism by which Crk...

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Share to Adherens Junctions
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Focal Adhesions

Share to Guanine Nucleotide Exchange Factors

Share to Hepatocyte Growth Factor

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Share to Rho Guanine Nucleotide Exchange Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 12857867
DOI: 10.1091/mbc.e02-08-0497
PMCID: PMC165679

Genes

GIT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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