Article
Contribution of MIC-A polymorphism to type 1 diabetes mellitus in Basques.
Annals of the New York Academy of Sciences - 1 Apr 2002
Bilbao J Ramón, Martín-Pagola Ainhoa, Calvo Begoña, Perez de Nanclares Guiomar, Gepv-N, Castaño Luis
Abstract excerpt
The maximum genetic susceptibility to type 1 diabetes (T1DM) in Basques is conferred by extended HLA haplotype F1C30-DR3-DQ2-DPB1*0202. Due to the strong linkage disequilibrium within the haplotype, it is difficult to determine which individual allele shows the strongest association with T1DM. Recent studies of the MIC-A gene have shown an HLA-independent association of allele A5 with T1DM and A5.1 with Addison's...
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