Article
MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: an association and meta-analysis.
Molecular immunology - 1 Apr 2007
Alizadeh Behrooz Z, Eerligh Peter, van der Slik Arno R, Shastry Arun, Zhernakova Alexandra, Valdigem Gustavo, Bruining Jan G, Sanjeevi Carani B, Wijmenga Cisca, Roep Bart O, Koeleman Bobby P C
Abstract excerpt
The association of the HLA complex on chromosome 6 does not explain total linkage of the HLA region to Type 1 Diabetes (T1D), leading to the hypothesis that there may be additional causal genes in the HLA region for immune-related disorders. Reports on the MHC Class I chain-related A (MICA) gene as candidate for association with T1D are contradicting. We investigated whether variation in MICA is associated to T1D...
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