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Article

Polymorphism in the transmembrane region of the MICA gene and type 1 diabetes.

Journal of pediatric endocrinology & metabolism : JPEM - 1 May 2000

Lee Y J, Huang F Y, Wang C H, Lo F S, Tsan K W, Hsu C H, Huang C Y, Chang S C, Chang J G

Abstract excerpt

Although MHC class II genes have a stronger association with type 1 diabetes than MHC class I genes, studies have shown that MHC class I molecules play an independent role in the etiology of type 1 diabetes, and the existence of susceptibility genes within a segment of MHC between the HLA-B and TNF genes has been predicted, where MHC class I chain-related gene A (MICA) resides. MICA has a triplet repeat...

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Share to Diabetes Mellitus, Type 1
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Globins

Share to Histocompatibility Antigens Class I

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Share to Membrane Proteins

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Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 10803866
DOI: 10.1515/jpem.2000.13.5.489

Genes

MICA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Polymorphism in the transmembrane region of the MICA gene and type 1 diabetes.PMID 10803866Read ↗

Association of MHC Class I chain-related A (MIC-A) gene polymorphism with Type I diabetesSemantic proximity Read ↗

MICA gene polymorphism in the pathogenesis of type 1 diabetes.Semantic proximity Read ↗

Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden.Semantic proximity Read ↗

MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: an association and meta-analysis.Semantic proximity Read ↗

Microsatellite allele 5 of MHC class I chain-related gene a increases the risk for insulin-dependent diabetes mellitus in latvians.Semantic proximity Read ↗

MIC-A genotypes 4/5.1 and 9/9 are positively associated with type 1 diabetes mellitus in Brazilian population.Semantic proximity Read ↗

Association of MHC class I chain related gene-A microsatellite polymorphism with the susceptibility to T1DM and LADA in Czech adult patients.Semantic proximity Read ↗

MICA polymorphism is associated with type 1 diabetes in the Korean population.Semantic proximity Read ↗

Microsatellite allele A5.1 of MHC class I chain-related gene A is associated with latent autoimmune diabetes in adults in Latvia.Semantic proximity Read ↗

Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.Semantic proximity Read ↗

Independent association of tumor necrosis factor polymorphism with type 1 diabetes susceptibility.Semantic proximity Read ↗

Heterozygosity for MICA5.0/MICA5.1 and HLA-DR3-DQ2/DR4-DQ8 are independent genetic risk factors for latent autoimmune diabetes in adults.Semantic proximity Read ↗

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