Article
MHC class I chain-related gene alleles 5 and 5.1 are transmitted more frequently to type 1 diabetes offspring in HBDI families.
Annals of the New York Academy of Sciences - 1 Apr 2002
Zake L Nikitina, Ghaderi M, Park Y S, Babu S, Eisenbarth G, Sanjeevi C B
Abstract excerpt
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by autoimmune destruction of pancreatic beta cells. Genetic and environmental factors contribute in this disease. There is evidence that MHC class I chain-related gene (MIC-A) plays a role in the susceptibility to this and other autoimmune diseases. There are five alleles of the MIC-A gene, which consist of different repetitions of GCT. In...
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