Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein localization in the human eye and genetic screen of opticin.

Human molecular genetics - 15 May 2002

Friedman James S, Faucher Mathieu, Hiscott Paul, Biron Vincent L, Malenfant Mario, Turcotte Pierre, Raymond Vincent, Walter Michael A

Abstract excerpt

The opticin (OPTC) gene encodes a protein that is a member of the small leucine-rich repeat protein (SLRP) family. OPTC is located on chromosome 1q31-q32 within an age-related macular degeneration (AMD) susceptibility locus. We have developed an affinity-purified N-terminal anti-opticin antibody and used it to examine opticin expression in human eye tissues. The antibody was also used for opticin protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Matrix Proteins
Share to Eye

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glaucoma

Share to Glaucoma, Open-Angle

Share to Immunoblotting

Share to Macular Degeneration

Share to Organ Specificity

Share to Proteoglycans

Source

Identifiers

PMID: 12019215
DOI: 10.1093/hmg/11.11.1333

Genes

OPTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein localization in the human eye and genetic screen of opticin.PMID 12019215Read ↗

Cloning and characterization of opticin cDNA: evaluation as a candidate for canine oculo-skeletal dysplasia.Semantic proximity Read ↗

Adult-onset primary open-angle glaucoma caused by mutations in optineurin.Semantic proximity Read ↗

Optineurin in primary open angle glaucoma.Semantic proximity Read ↗

Different optineurin mutation pattern in primary open-angle glaucoma.Semantic proximity Read ↗

Posttranslational Modifications, Localization, and Protein Interactions of Optineurin, the Product of a Glaucoma GeneSemantic proximity Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma.Semantic proximity Read ↗

Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG.Semantic proximity Read ↗

Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterization of the protein in the eye.Semantic proximity Read ↗

Visual impairment in an optineurin mouse model of primary open-angle glaucoma.Semantic proximity Read ↗

Optineurin and Its Mutants: Molecules Associated with Some Forms of GlaucomaSemantic proximity Read ↗

Defining the pathogenicity of optineurin in juvenile open-angle glaucoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.