Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterization of the protein in the eye.

doi:10.1167/iovs.11-9047

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Article

Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterization of the protein in the eye.

Investigative ophthalmology & visual science - 24 Jul 2012

Sharma Shiwani, Burdon Kathryn P, Chidlow Glyn, Klebe Sonja, Crawford April, Dimasi David P, Dave Alpana, Martin Sarah, Javadiyan Shahrbanou, Wood John P M, Casson Robert, Danoy Patrick, Griggs Kim, Hewitt Alex W, Landers John, Mitchell Paul, Mackey David A, Craig Jamie E

Abstract excerpt

PURPOSE: Glaucoma is the leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG) is the most common subtype. We recently reported association of genetic variants at chromosomal loci, 1q24 and 9p21, with POAG. In this study, we determined association of the most significantly associated single nucleotide polymorphism (SNP) rs4656461, at 1q24 near the TMCO1 gene, with the clinical...

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Identifiers

PMID: 22714896
DOI: 10.1167/iovs.11-9047

Genes

TMCO1

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Source receipt: pubmed, retrieved 6 Sept 2026.

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