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Article

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.

Nucleic acids research - 1 Apr 2013

Aldred Katie J, McPherson Sylvia A, Turnbough Charles L, Kerns Robert J, Osheroff Neil

Abstract excerpt

Although quinolones are the most commonly prescribed antibacterials, their use is threatened by an increasing prevalence of resistance. The most common causes of quinolone resistance are mutations of a specific serine or acidic residue in the A subunit of gyrase or topoisomerase IV. These amino acids are proposed to serve as a critical enzyme-quinolone interaction site by anchoring a water-metal ion bridge that...

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Identifiers

PMID: 23460203
DOI: 10.1093/nar/gkt124
PMCID: PMC3632122

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Source receipt: pubmed, retrieved 7 Sept 2026.

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