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Article

Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.

The Journal of biological chemistry - 26 Jul 2002

Ho Chi S, Marinescu Vlad, Steinhilb Michelle L, Gaut James R, Turner R Scott, Stuenkel Edward L

Abstract excerpt

X11 proteins have been shown to modulate metabolism of the amyloid precursor protein (APP) and to reduce the secretion of beta-amyloid peptides (Abeta) that are associated with Alzheimer's disease. Whereas X11alpha interacts with APP via its phosphotyrosine-binding domain, recent reports indicate that additional regulatory interactions involve the N terminus of X11. Here we report that the syntaxin-1a-binding...

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Source

Identifiers

PMID: 12016213
DOI: 10.1074/jbc.M201823200

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.PMID 12016213Read ↗

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