Article
The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.
The Journal of biological chemistry - 12 Jun 1998
Borg J P, Yang Y, De Taddéo-Borg M, Margolis B, Turner R S
Abstract excerpt
Constitutive amyloid precursor protein (APP) metabolism results in the generation of soluble APP (APPs) and Abeta peptides, including Abeta40 and Abeta42-the major component of amyloid plaques in Alzheimer's disease brain. The phosphotyrosine binding (PTB) domain of X11 binds to a peptide contain...
Topics
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Aspartic Acid Endopeptidases
- Binding Sites
- Cell Line
- Cloning, Molecular
- Culture Media, Conditioned
- Endopeptidases
- Gene Expression