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Article

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.

The Journal of biological chemistry - 12 Jun 1998

Borg J P, Yang Y, De Taddéo-Borg M, Margolis B, Turner R S

Abstract excerpt

Constitutive amyloid precursor protein (APP) metabolism results in the generation of soluble APP (APPs) and Abeta peptides, including Abeta40 and Abeta42-the major component of amyloid plaques in Alzheimer's disease brain. The phosphotyrosine binding (PTB) domain of X11 binds to a peptide containing a YENPTY motif found in the carboxyl terminus of APP. We have cloned the full-length X11 gene now referred to as...

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Identifiers

PMID: 9614075
DOI: 10.1074/jbc.273.24.14761

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.PMID 9614075Read ↗

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Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.Semantic proximity Read ↗

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