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Article

X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.

Neurobiology of disease - 1 Oct 2009

Saluja Inderjeet, Paulson Henry, Gupta Ashwin, Turner R Scott

Abstract excerpt

The neuronal adaptor protein X11alpha/mint-1/APBA-1 binds to the cytoplasmic domain of the amyloid precursor protein (APP) to modulate its trafficking and metabolism. We investigated the consequences of reducing X11alpha in a mouse model of Alzheimer's disease (AD). We crossed hAPPswe/PS-1DeltaE9 transgenic (AD tg) mice with X11alpha heterozygous knockout mice in which X11alpha expression is reduced by...

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Identifiers

PMID: 19631749
DOI: 10.1016/j.nbd.2009.07.006
PMCID: PMC2742573

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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