Article
X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.
Neurobiology of disease - 1 Oct 2009
Saluja Inderjeet, Paulson Henry, Gupta Ashwin, Turner R Scott
Abstract excerpt
The neuronal adaptor protein X11alpha/mint-1/APBA-1 binds to the cytoplasmic domain of the amyloid precursor protein (APP) to modulate its trafficking and metabolism. We investigated the consequences of reducing X11alpha in a mouse model of Alzheimer's disease (AD). We crossed hAPPswe/PS-1DeltaE9 transgenic (AD tg) mice with X11alpha heterozygous knockout mice in which X11alpha expression is reduced by...
Topics
- Adaptor Proteins, Signal Transducing
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Brain
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Gene Expression Regulation
- Humans
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic