Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.

The Journal of biological chemistry - 19 Nov 2004

Lee Ju-Hyun, Lau Kwok-Fai, Perkinton Michael S, Standen Claire L, Rogelj Boris, Falinska Agnieszka, McLoughlin Declan M, Miller Christopher C J

Abstract excerpt

Accumulation of cerebral amyloid beta-protein (Abeta) is believed to be part of the pathogenic process in Alzheimer's disease. Abeta is derived by proteolytic cleavage from a precursor protein, the amyloid precursor protein (APP). APP is a type-1 membrane-spanning protein, and its carboxyl-terminal intracellular domain binds to X11beta, a neuronal adaptor protein. X11beta has been shown to inhibit the production...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Northern

Share to Cadherins

Share to Cell Membrane

Share to Crosses, Genetic

Share to Immunoblotting

Share to Neurons

Source

Identifiers

PMID: 15347685
DOI: 10.1074/jbc.M405602200

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.PMID 15347685Read ↗

The Neuronal Adaptor Protein X11α Reduces Aβ Levels in the Brains of Alzheimer's APPswe Tg2576 Transgenic MiceSemantic proximity Read ↗

X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.Semantic proximity Read ↗

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.Semantic proximity Read ↗

Loss of Function of ATXN1 Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor ProteinSemantic proximity Read ↗

X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.Semantic proximity Read ↗

Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila.Semantic proximity Read ↗

Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.Semantic proximity Read ↗

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read ↗

Amyloid precursor protein interacts with notch receptorsSemantic proximity Read ↗

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domainsSemantic proximity Read ↗

Increased ATP-Binding Cassette Transporter A1 Expression in Alzheimer's Disease Hippocampal NeuronsSemantic proximity Read ↗

Deletion of the 7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.