Article
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.
The Journal of biological chemistry - 26 Jul 2002
Sweet Douglas H, Miller David S, Pritchard John B, Fujiwara Yuko, Beier David R, Nigam Sanjay K
Abstract excerpt
To begin to develop in vivo model systems for the assessment of the contributions of specific organic anion transporter (OAT) family members to detoxification, development, and disease, we carried out a targeted disruption of the murine organic anion transporter 3 (Oat3) gene. Surviving Oat3(-/-) animals appear healthy, are fertile, and do not exhibit any gross morphological tissue abnormalities. No Oat3 mRNA...
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