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Cloning and Functional Expression of A Mouse Liver Organic Cation Transporter

1 May 1999

Abstract excerpt

Hepatic uptake of organic cations is essential for the metabolism and secretion of numerous endobiotics and drugs. Several hepatic organic cation transporters have been kinetically defined, yet have not been isolated or cloned. We have isolated a complementary DNA (cDNA) from both murine liver and kidney cDNA libraries (mOct1/Slc22a1), and have functionally expressed it in Xenopus laevis oocytes. Although...

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PMID: 10216142
DOI: 10.1002/hep.510290530

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