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Article

Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis in Oatp1c1 Deficiency.

Thyroid : official journal of the American Thyroid Association - 1 Jan 2020

Admati Inbal, Wasserman-Bartov Talya, Tovin Adi, Rozenblat Rotem, Blitz Einat, Zada David, Lerer-Goldshtein Tali, Appelbaum Lior

Abstract excerpt

Background: The thyroid hormones (THs) triiodothyronine (T3) and thyroxine (T4) are crucial regulators of brain development and function. Cell-specific transporter proteins facilitate TH uptake and efflux across the cell membrane, and insufficient TH transport causes hypothyroidism and mental retardation. Mutations in the TH transporters monocarboxylate transporter 8 (MCT8, SLC16A2) and the organic...

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PMID: 31797746
DOI: 10.1089/thy.2019.0320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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