Article
Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration.
The Journal of biological chemistry - 10 Sept 2004
Shin Nah-Young, Dise Rebecca S, Schneider-Mergener Jens, Ritchie Marylyn D, Kilkenny Dawn M, Hanks Steven K
Abstract excerpt
Crk-associated substrate (p130(CAS) or CAS) is a major integrin-associated Src substrate that undergoes tyrosine phosphorylation at multiple YXXP motifs in its substrate domain (SD) to create docking sites for SH2-containing signaling effectors. Notably, recruitment of Crk adaptor proteins to the CAS SD sites is implicated in promoting cell migration. However, it is unclear which or how many of the 15 CAS SD YXXP...
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