Article
A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains.
The Journal of biological chemistry - 19 Jul 2002
Wang Yan, Yamaguchi Kazunori, Wada Tadashi, Hata Keiko, Zhao Xuejian, Fujimoto Toyoshi, Miyagi Taeko
Abstract excerpt
The ganglioside-specific sialidase Neu3 has been suggested to play essential roles in regulation of cell surface functions because of its major localization in the plasma membrane and strict substrate preference for gangliosides involved in signal transduction. Here we show that human Neu3 sialidase is enriched in caveolae microdomains and closely associates with caveolin like other caveolin-binding signaling...
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