Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides.

The Journal of biological chemistry - 22 Mar 2002

Miljan Erik A, Meuillet Emmanuelle J, Mania-Farnell Barbara, George David, Yamamoto Hirotaka, Simon Hans-Georg, Bremer Eric G

Abstract excerpt

Ganglioside GM3 inhibits epidermal growth factor (EGF)-dependent cell proliferation in a variety of cell lines. Both in vitro and in vivo, this glycosphingolipid inhibits the kinase activity of the EGF receptor (EGFR). Furthermore, membrane preparations containing EGFR can bind to GM3-coated surfaces. These data suggest that GM3 may interact directly with the EGFR. In this study, the interaction of gangliosides...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Complementary
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to ErbB Receptors

Share to G(M1) Ganglioside

Share to G(M2) Ganglioside

Share to Gangliosides

Share to Insecta

Source

Identifiers

PMID: 11796728
DOI: 10.1074/jbc.M111669200

Genes

EGFR
ECD
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides.PMID 11796728Read ↗

GM3 content modulates the EGF-activated p185c-neu levels, but not those of the constitutively activated oncoprotein p185neu.Semantic proximity Read ↗

A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains.Semantic proximity Read ↗

Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts.Semantic proximity Read ↗

GD1b-derived gangliosides modulate FcεRI endocytosis in mast cells.Semantic proximity Read ↗

The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling.Semantic proximity Read ↗

Quantification of ErbB3 receptor density on human breast cancer cells, using a stable radio-labeled mutant of NRG1beta.Semantic proximity Read ↗

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.Semantic proximity Read ↗

Prostaglandin E2 receptor EP3alpha subtype: the role of N-glycosylation in ligand binding as revealed by site-directed mutagenesis.Semantic proximity Read ↗

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.Semantic proximity Read ↗

Activation of tyrosine kinase of EGFR induces Gbetagamma-dependent GRK-EGFR complex formation.Semantic proximity Read ↗

Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase.Semantic proximity Read ↗

Chinese hamster ovary cells lacking GM1 and GD1a synthesize gangliosides upon transfection with human GM2 synthaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.