An interaction between SLC35A1 and ST3Gal4 is differentially affected by CDG-causing mutations in the SLC35A1 gene.

doi:10.1016/j.bbrc.2022.10.019

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Article

An interaction between SLC35A1 and ST3Gal4 is differentially affected by CDG-causing mutations in the SLC35A1 gene.

Biochemical and biophysical research communications - 20 Dec 2022

Wiertelak Wojciech, Olczak Mariusz, Maszczak-Seneczko Dorota

Abstract excerpt

The sialylation of glycoconjugates is performed by a variety of sialyltransferases using CMP-sialic acid (CMP-Sia) as a substrate. Sialylation requires the translocation of CMP-Sia across the Golgi membranes. This function has been assigned to SLC35A1, the only CMP-Sia transporter identified to date. Mutations in the SLC35A1 gene cause a subtype of congenital disorder of glycosylation (CDG). Over the past several...

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PMID: 36257191
DOI: 10.1016/j.bbrc.2022.10.019

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