Blood and spleen lymphocytes as targets for immunotoxic effects in the rat--a comparison.

doi:10.1016/s0300-483x(02)00033-1

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Article

Blood and spleen lymphocytes as targets for immunotoxic effects in the rat--a comparison.

Toxicology - 5 Jun 2002

Nygaard Unni Cecilie, Løvik Martinus

Abstract excerpt

Traditionally, immunotoxicological studies in the rat have been performed by measuring the effect of chemical substances on spleen lymphocytes in vivo and in vitro. However, rat blood lymphocytes may be more relevant than spleen cells for comparison with human blood lymphocytes. Further, lymphocytes in blood may be a more sensitive indicator of immunotoxic effects than spleen lymphocytes. Finally, in longitudinal...

Topics

Animals
Cell Count
Flow Cytometry
Immunotoxins
Lymphocyte Count
Lymphocytes
Male
Organ Size
Phenotype
Rats
Spleen
Xenobiotics

Source

Open in PubMed

Identifiers

PMID: 12007855
DOI: 10.1016/s0300-483x(02)00033-1

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