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Article

The popliteal lymph node assay in mice: screening of drugs and other chemicals for immunotoxic hazard.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Dec 1996

Goebel C, Griem P, Sachs B, Bloksma N, Gleichmann E

Abstract excerpt

The popliteal lymph node assay (PLNA) in mice represents a predictive test for assessing the sensitizing (allergenic and autoimmunogenic) potential of drugs and low molecular weight chemicals. Measuring activation of the draining lymph node of the hind paw, the PLNA facilitates the detection and...

Topics

Administration, Inhalation
Administration, Oral
Animals
Drug Hypersensitivity
Hindlimb
Immunotoxins
Injections, Intravenous
Lymph Nodes
Mice
Molecular Weight
Phenotype
Reproducibility of Results

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Toxicity Tests

Source

Identifiers

PMID: 8988408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8988408-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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