Article
3-Methylindole-induced splenotoxicity: functional analysis of immune parameters and lymphocyte phenotyping by flow cytometry.
Toxicology and applied pharmacology - 1 Jul 1991
Updyke L W, Yoon H L, Robinson J P, Kiorpes A L, Marcus C B, Pfeifer R W
Abstract excerpt
In this laboratory, 3-methylindole (3-MI), a pneumotoxic metabolite of L-tryptophan that forms in the digestive tract of humans and ruminants, has been demonstrated to be toxic to rat and mouse splenic cells both in vitro and in vivo. The present studies examine whether the reduction in nucleated splenic cells is associated with alterations in: (1) immune functioning (e.g., B and T cell mitogenic responses to...
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