Development of a flow cytometry assay for the identification and differentiation of chemicals with the potential to elicit irritation, IgE-mediated, or T cell-mediated hypersensitivity responses.

Abstract excerpt

These studies were conducted to investigate the potential use of a flow cytometric analysis method for the identification and differentiation of chemicals with the capacity to induce irritation, IgE- or T cell-mediated hypersensitivity responses. An initial study investigated the ability of equally sensitizing concentrations (determined by local lymph node assay) of IgE-mediated (Toluene Diisocyanate-TDI) and T...

Topics

• Administration, Cutaneous
• Animals
• Dermatitis, Contact
• Dinitrofluorobenzene
• Dose-Response Relationship, Drug
• Edema
• Female
• Flow Cytometry
• Hypersensitivity
• Immunoglobulin G