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Article

Validation of immune function testing during a 4-week oral toxicity study with FK506.

Toxicology letters - 1 Apr 2004

Ulrich P, Paul G, Perentes E, Mahl A, Roman D

Abstract excerpt

Assessment of the immune system's capability to respond to antigens with the generation of specific antibodies, whilst under the influence of a test article, is required in toxicity tests according to the European guideline for repeated dose toxicity testing of medicinal products. The purpose of this study in rats was to validate methodology for the determination of Keyhole Limpet Haemocyanin (KLH)-specific...

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Identifiers

PMID: 15093257
DOI: 10.1016/j.toxlet.2003.12.069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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