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Article

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.

Human molecular genetics - 1 Apr 2009

Hagemann Tracy L, Boelens Wilbert C, Wawrousek Eric F, Messing Albee

Abstract excerpt

Alexander disease (AxD) is a primary disorder of astrocytes caused by dominant mutations in the gene for glial fibrillary acidic protein (GFAP). These mutations lead to protein aggregation and formation of Rosenthal fibers, complex astrocytic inclusions that contain GFAP, vimentin, plectin, ubiquitin, Hsp27 and alphaB-crystallin. The small heat shock protein alphaB-crystallin (Cryab) regulates GFAP assembly, and...

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Source

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Identifiers

PMID: 19129171
DOI: 10.1093/hmg/ddp013
PMCID: PMC2655774

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.PMID 19129171Read ↗

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Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairmentSemantic proximity Read ↗

Alexander disease: models, mechanisms, and medicine.Semantic proximity Read ↗

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease.Semantic proximity Read ↗

Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.Semantic proximity Read ↗

Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance.Semantic proximity Read ↗

Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease.Semantic proximity Read ↗

Glial fibrillary acidic protein is pathologically modified in Alexander disease.Semantic proximity Read ↗

Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.Semantic proximity Read ↗

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STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.Semantic proximity Read ↗

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