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Article

GFAP expression as an indicator of disease severity in mouse models of Alexander disease.

ASN neuro - 1 Jan 2013

Jany Paige L, Hagemann Tracy L, Messing Albee

Abstract excerpt

AxD (Alexander disease) is a rare disorder caused by heterozygous mutations in GFAP (glial fibrillary acidic protein) resulting in accumulation of the GFAP protein and elevation of Gfap mRNA. To test whether GFAP itself can serve as a biomarker of disease status or progression, we investigated two independent measures of GFAP expression in AxD mouse models, one using a genetic reporter of promoter activity and...

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Identifiers

PMID: 23432455
DOI: 10.1042/AN20130003
PMCID: PMC3604736

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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GFAP expression as an indicator of disease severity in mouse models of Alexander disease.PMID 23432455Read ↗

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Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.Semantic proximity Read ↗

Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model.Semantic proximity Read ↗

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes.Semantic proximity Read ↗

Alexander disease: models, mechanisms, and medicine.Semantic proximity Read ↗

Clinical characteristics of Alexander disease.Semantic proximity Read ↗

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.Semantic proximity Read ↗

STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.Semantic proximity Read ↗

Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance.Semantic proximity Read ↗

Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.Semantic proximity Read ↗

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.Semantic proximity Read ↗

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