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p120-catenin in cancer – mechanisms, models and opportunities for intervention

15 Aug 2013

Abstract excerpt

The epithelial adherens junction is an E-cadherin-based complex that controls tissue integrity and is stabilized at the plasma membrane by p120-catenin (p120, also known as CTNND1). Mutational and epigenetic inactivation of E-cadherin has been strongly implicated in the development and progression of cancer. In this setting, p120 translocates to the cytosol where it exerts oncogenic properties through aberrant...

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PMID: 23950111
DOI: 10.1242/jcs.134411

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