The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

doi:10.1002/j.1460-2075.1995.tb07182.x

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Article

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

The EMBO journal - 1 May 1995

Zhu L, Enders G, Lees J A, Beijersbergen R L, Bernards R, Harlow E

Abstract excerpt

Unregulated expression of either the retinoblastoma protein (pRB) or the related protein p107 can cause growth arrest of sensitive cells in the G1 phase of the cell cycle. However, growth arrests mediated by p107 and pRB are not identical. Through structure-function and co-expression analyses we...

Topics

3T3 Cells
Animals
Base Sequence
Carrier Proteins
Cell Cycle
Cell Cycle Proteins
Cell Division
Cell Line
Cyclin-Dependent Kinases
Cyclins
DNA Primers
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

E2F Transcription Factors

Humans

Mice

Molecular Sequence Data

Mutation

Nuclear Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7743997
DOI: 10.1002/j.1460-2075.1995.tb07182.x
PMCID: PMC398289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7743997-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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