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Article

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

The EMBO journal - 1 May 1995

Zhu L, Enders G, Lees J A, Beijersbergen R L, Bernards R, Harlow E

Abstract excerpt

Unregulated expression of either the retinoblastoma protein (pRB) or the related protein p107 can cause growth arrest of sensitive cells in the G1 phase of the cell cycle. However, growth arrests mediated by p107 and pRB are not identical. Through structure-function and co-expression analyses we have dissected the p107 molecule into two domains that independently are able to block cell cycle progression. One...

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Identifiers

PMID: 7743997
DOI: 10.1002/j.1460-2075.1995.tb07182.x
PMCID: PMC398289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.PMID 7743997Read ↗

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Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and DifferentiationSemantic proximity Read ↗

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Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.Semantic proximity Read ↗

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