Article
p53 mutation arising in Arg72 allele in the tumorigenesis and development of carcinoma of the urinary tract.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2002
Furihata Mutsuo, Takeuchi Tamotsu, Matsumoto Manabu, Kurabayashi Atsushi, Ohtsuki Yuji, Terao Naotami, Kuwahara Morimasa, Shuin Taro
Abstract excerpt
PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53. Furthermore, the Arg72-containing allele is preferentially mutated and retained in various human tumors, suggesting that polymorphic residue within p53 modifies mutant behavior. We studied to determine whether Arg72 could be a risk factor for p53...
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