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Article

The influence of the p53 codon 72 polymorphism on ovarian carcinogenesis and prognosis.

Cancer gene therapy - 1 Jan 2000

Buller R E, Sood A, Fullenkamp C, Sorosky J, Powills K, Anderson B

Abstract excerpt

The frequency of dysfunction of the p53 tumor suppressor gene in cancer has made the concept of gene replacement therapy with wild-type p53 an attractive strategy. Codon 72 of the p53 gene is highly polymorphic with a reported arginine/proline allelotype frequency of 0.65/0.35 for Caucasians and a reversal of this ratio in African-Americans. Ovarian cancer is more common and less aggressive in Caucasians. The...

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PMID: 9253509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The influence of the p53 codon 72 polymorphism on ovarian carcinogenesis and prognosis.PMID 9253509Read ↗

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