Article
Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and predictive impact of proline related genotype in advanced tumors in an ethnic Kashmiri population.
Cancer genetics and cytogenetics - 1 Dec 2010
Pandith Arshad A, Shah Zafar A, Khan Nighat P, Rasool Roohi, Afroze Dil, Yousuf Adfar, Wani Saleem, Siddiqi Mushtaq
Abstract excerpt
Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on bladder cancer risk. A case-control study was conducted and we observed the genotype distribution of TP53 Arg72Pro SNP, to elucidate the possible role of this SNP as risk factor in urinary bladder cancer (UBC)...
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