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Article

Selective loss of codon 72 proline p53 and frequent mutational inactivation of the retained arginine allele in colorectal cancer.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Schneider-Stock Regine, Boltze Carsten, Peters Brigitte, Szibor Reinhard, Landt Olfert, Meyer Frank, Roessner Albert

Abstract excerpt

According to recent reports, some cancer types exhibit nonrandom allele loss at codon 72 in exon 4 of the p53 gene [coding for proline (72Pro) or arginine (72Arg)]. To clarify this phenomenon for colorectal cancer and to find out if this preferential loss might have any functional significance, p53 loss of heterozygosity (LOH) and p53 mutations were investigated in a group of 61 colorectal cancers and 28 liver...

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Source

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Identifiers

PMID: 15548361
DOI: 10.1593/neo.04178
PMCID: PMC1531656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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