Article
The C825T polymorphism in the human G-protein beta3 subunit gene is not associated with diabetic nephropathy in Type I diabetes mellitus.
Diabetologia - 1 Nov 1998
Fogarty D G, Zychma M J, Scott L J, Warram J H, Krolewski A S
Abstract excerpt
In Type I (insulin-dependent) diabetes mellitus a genetic predisposition exists to nephropathy and is related to parental hypertension. Enhanced G-protein activation, a cellular phenotype observed in cultured cells from patients with essential hypertension, was recently documented in Type I diabe...
Topics
- Adolescent
- Adult
- Blood Pressure
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Exons
- Female
- GTP-Binding Proteins
- Genotype
- Glycated Hemoglobin
- Humans
- Macromolecular Substances
- Male
- Point Mutation
- Polymorphism, Genetic