Article
A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities.
Cancer research - 15 Feb 2000
Li L C, Chui R M, Sasaki M, Nakajima K, Perinchery G, Au H C, Nojima D, Carroll P, Dahiya R
Abstract excerpt
E-cadherin plays a critical role in many aspects of cell adhesion, epithelial development, and the establishment and maintenance of epithelial polarity. The loss of the adhesive function of E-cadherin is a critical step in the promotion of epithelial cells to a more malignant phenotype. We identified a C/A single nucleotide polymorphism at -160 from the transcriptional start site of the E-cadherin gene promoter....
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