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Article

Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer.

The American journal of pathology - 1 Aug 2000

Loukola A, Vilkki S, Singh J, Launonen V, Aaltonen L A

Abstract excerpt

Microsatellite instability (MSI) is characteristic of hereditary nonpolyposis colorectal cancer, and occurs in a subset (10 to 15%) of unselected colorectal cancer cases. In hereditary nonpolyposis colorectal cancer, MSI is caused by defects in five mismatch repair genes, and in sporadic cases the main cause seems to be somatic MLH1 promoter methylation. Most likely additional hereditary nonpolyposis colorectal...

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Share to Carrier Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

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Identifiers

PMID: 10934138
DOI: 10.1016/S0002-9440(10)64546-4
PMCID: PMC1850126

Genes

MLH3
MSH3
MSH6
BAX
MBD4
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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