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Article

Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation.

Genes, chromosomes & cancer - 1 Sept 2000

Planck M, Wenngren E, Borg A, Olsson H, Nilbert M

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by a germline mutation in one of several DNA repair genes, which in the tumors is reflected as microsatellite instability (MSI). MSI+ tumors have been found to carry somatic frameshift mutations in mononucleotide repeats within the coding regions of several genes involved in growth control, apoptosis, and DNA repair, e.g., TGFBRII, BAX, IGFIIR, TCF4,...

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Source

Identifiers

PMID: 10918391
DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1004>3.0.co;2-r

Genes

BAX
MSH2
MSH3
MSH6
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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