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Article

Over Expression of ID-1 in Prostate Cancer

1 Jun 2002

Abstract excerpt

PURPOSE: The helix-loop-helix protein Id-1 serves to prevent basic helix-loop-helix transcription factors from binding to DNA, thus, inhibiting the transcription of differentiation associated genes. Over expression of Id-1 has been reported in certain tumors, such as breast, esophageal, pancreatic and medullary thyroid cancers. In Noble rats we have previously demonstrated that up-regulation of Id-1 is closely...

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PMID: 11992094
DOI: 10.1016/s0022-5347(05)65044-6

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