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Article

Non-redundant inhibitor of differentiation (Id) gene expression and function in human prostate epithelial cells

15 Mar 2006

Abstract excerpt

BACKGROUND: The four Id (inhibitor of differentiation) proteins (Id1, Id2, Id3, and Id4) dimerize and neutralize the transcriptional activity of basic helix-loop-helix (bHLH) proteins. The Id proteins negatively regulate differentiation and promote proliferation hence the expression of specific subsets of Id proteins is high in many different types of cancers. However, the expression of all the Id isoforms and...

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PMID: 16541417
DOI: 10.1002/pros.20366

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