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Article

The molecular action of testis-determining factors SRY and SOX9.

Novartis Foundation symposium - 1 Jan 2002

Harley Vincent R

Abstract excerpt

Despite 10 years of work since the discovery of SRY, little is known about its biochemical function. The HMG domain, a DNA-binding and DNA-bending motif, plays a central role, being the only region conserved between species and the site of almost all clinical mutations causing XY gonadal dysgenesis. By contrast, SOX9 harbours a number of highly conserved regions, including two domains required for maximal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sex-Determining Region Y Protein

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Source

Identifiers

PMID: 11990798

Genes

SOX9
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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