Article
The role of SOX9 in autosomal sex reversal and campomelic dysplasia.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Nov 1995
Schafer A J, Dominguez-Steglich M A, Guioli S, Kwok C, Weller P A, Stevanovic M, Weissenbach J, Mansour S, Young I D, Goodfellow P N
Abstract excerpt
In eutherian mammals, the Y-chromosome gene SRY is required for induction of testis development. Although the Y chromosome is sex determining, loci located elsewhere in the genome participate in the complex cascade of genetic interactions required to form a testis. Male to female sex reversal (46...
Topics
- Biological Evolution
- Chromosome Aberrations
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Disorders of Sex Development
- Female
- High Mobility Group Proteins
- Humans
- Male
- Mutation
- Osteochondrodysplasias
- SOX9 Transcription Factor
- Sex Differentiation