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Article

The role of SRY in mammalian sex determination.

Acta paediatrica Japonica : Overseas edition - 1 Aug 1996

Fechner P Y

Abstract excerpt

The gene SRY (sex determining region of the Y), located at the distal region of the short arm of the Y chromosome, is necessary for male sex determination in mammals. SRY initiates the cascade of steps necessary to form a testis from an undifferentiated gonad. The SRY gene encodes an HMG (High Mobility Group) protein which may act as a transcription factor by binding to double stranded DNA and then bending the...

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Source

Identifiers

PMID: 8840551
DOI: 10.1111/j.1442-200x.1996.tb03512.x

Genes

SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of SRY in mammalian sex determination.PMID 8840551Read ↗

Molecular basis of mammalian sexual determination: activation of Mullerian inhibiting substance gene expression by SRYSemantic proximity Read ↗

The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9]Semantic proximity Read ↗

Two new novel point mutations localized upstream and downstream of the HMG box region of the SRY gene in three Indian 46,XY females with sex reversal and gonadal tumour formationSemantic proximity Read ↗

A novel missense mutation in the HMG box region of the SRY gene in a Japanese patient with an XY sex reversal.Semantic proximity Read ↗

Mutational analysis of SRY in XY females.Semantic proximity Read ↗

Testis-determining factor and Y-linked sex reversal.Semantic proximity Read ↗

SRY protein function in sex determination: thinking outside the box.Semantic proximity Read ↗

XY sex reversal associated with a deletion 5' to the SRY "HMG box" in the testis-determining region.Semantic proximity Read ↗

Structure–function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determinationSemantic proximity Read ↗

Three novel SRY mutations in XY gonadal dysgenesis and the enigma of XY gonadal dysgenesis cases without SRY mutations.Semantic proximity Read ↗

SEX IN THE 90s:<i>SRY</i>and the Switch to the Male PathwaySemantic proximity Read ↗

Identification of a new missense mutation (Gly95Glu) in a highly conserved codon within the high-mobility group box of the sex-determining region Y gene: report on a 46,XY female with gonadal dysgenesis and yolk-sac tumor.Semantic proximity Read ↗

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