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Article

The human p73 promoter: characterization and identification of functional E2F binding sites.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Seelan Ratnam S, Irwin Meredith, van der Stoop Petra, Qian Chiping, Kaelin William G, Liu Wanguo

Abstract excerpt

p73, a member of the p53 family, is overexpressed in many cancers. To understand the mechanism(s) underlying this overexpression, we have undertaken a detailed characterization of the human p73 promoter. The promoter is strongly activated in cells expressing exogenous E2F1 and suppressed by exogenous Rb. At least three functional E2F binding sites, located immediately upstream of exon 1 (at -284, -155 and -132)...

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Identifiers

PMID: 11988839
DOI: 10.1038/sj.neo.7900237
PMCID: PMC1531693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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