Article
Comparison of wild-type and class I integrase mutant-FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium.
The journal of gene medicine - 1 Dec 2003
Loewen Nils, Leske David A, Chen Yi, Teo Wu-Lin, Saenz Dyana T, Peretz Mary, Holmes Jonathan M, Poeschla Eric M
Abstract excerpt
BACKGROUND: In neonatal and adult rodent retina, substantial lentiviral vector expression has been detected primarily in retinal pigment epithelium (RPE), except in very young animals (2-5 days post-natal). In non-retinal tissues, studies of lentiviral vectors have utilized various controls. Among the most stringent are class I integrase mutants, which selectively block the integration reaction while leaving all...
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