Article
Reduction of cytochrome c oxidase by a second electron leads to proton translocation.
Nature - 2 May 2002
Ruitenberg Maarten, Kannt Aimo, Bamberg Ernst, Fendler Klaus, Michel Hartmut
Abstract excerpt
Cytochrome c oxidase, the terminal enzyme of cellular respiration in mitochondria and many bacteria, reduces O(2) to water. This four-electron reduction process is coupled to translocation (pumping) of four protons across the mitochondrial or bacterial membrane; however, proton pumping is poorly understood. Proton pumping was thought to be linked exclusively to the oxidative phase, that is, to the transfer of the...
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