Article
Microsatellite instability at tetranucleotide repeats in sporadic colorectal cancer in Japan.
Oncology reports - 1 Feb 2010
Yamada Kanae, Kanazawa Shinsaku, Koike Junichi, Sugiyama Hisahiko, Xu Can, Funahashi Kimihiko, Boland C Richard, Koi Minoru, Hemmi Hiromichi
Abstract excerpt
Most tumors of patients with Lynch syndrome and a fraction of sporadic colorectal cancers (CRCs) exhibit high levels of microsatellite instability (MSI) at mono- and dinucleotide repeat loci. A different type of instability, elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) has been found in non-colonic cancers. Our previous study demonstrated that EMAST is common in sporadic CRC....
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