Article
A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Diabetologia - 1 Aug 2008
Pearson T, Shultz L D, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini A A, Bottino R, Trucco M, Greiner D L
Abstract excerpt
AIMS/HYPOTHESIS: To develop and validate a new immunodeficient mouse strain that spontaneously develops a non-autoimmune hyperglycaemia to serve as a diabetic host for human islets and human beta stem and progenitor cells without the need for induction of hyperglycaemia by toxic chemicals with their associated side effects. METHODS: We generated and characterised a new strain of immunodeficient spontaneously...
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