Article
[Role of transforming growth factor beta-1 gene polymorphisms in the development of chronic allograft nephropathy in renal transplant recipients].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - 1 Jan 2000
Iñigo P, Lario S, Campistol J M, Bescós M, Campos B, Oppenheimer F
Abstract excerpt
BACKGROUND: Chronic allograft nephropathy (CAN) is the main cause of graft loss after the first year of transplantation, and renal biopsies show a predominance of fibrotic lesions. Human transforming growth factor beta-1 (TGF-beta 1) is the principal profibrogenetic cytokine which has been recently implicated in the development of CAN. Seven TGF-beta 1 gene polymorphisms have been recently described and some of...
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