Article
Bax is not the heterodimerization partner necessary for sustained anti-photoreceptor-cell-death activity of Bcl-2.
Investigative ophthalmology & visual science - 1 May 2002
Eversole-Cire Pamela, Chen Jeannie, Simon Melvin I
Abstract excerpt
PURPOSE: Ectopic expression of Bcl-2 in photoreceptors of certain mouse models of retinitis pigmentosa (RP) temporarily slows disease progression. The temporary effect produced by Bcl-2 may result from insufficient levels of functional complexes between Bcl-2 and additional proteins necessary for maintaining the anti-apoptotic activity of Bcl-2. Although the overexpression of Bax generally induces apoptosis, Bax...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.