Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice.

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Article

Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 2000

Nir I, Kedzierski W, Chen J, Travis G H

Abstract excerpt

The retinal degeneration slow or rds gene encodes rds/peripherin, an integral membrane glycoprotein in the outer segments of rod and cone photoreceptors. Mice homozygous for a null mutation in rds fail to develop outer segments and undergo subsequent degeneration of photoreceptors by the apoptotic pathway. Mutations in the human RDS gene are responsible for several forms of inherited blindness including...

Topics

Animals
Apoptosis
Cell Survival
Female
Gene Expression
Genotype
Humans
Intermediate Filament Proteins
Male
Membrane Glycoproteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Transgenic

Microscopy, Electron

Nerve Tissue Proteins

Peripherins

Photoreceptor Cells, Vertebrate

Proto-Oncogene Proteins c-bcl-2

Source

Open in PubMed Open full text

Identifiers

PMID: 10704489
PMCID: PMC6772515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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